Rapid Agent Restores Pleasure Seeking Ahead of Other Antidepressant Action
Read the full article Rapid Agent Restores Pleasure Seeking Ahead of Other Antidepressant Action at NeuroscienceNews.com.
A drug being studied as a fast-acting mood-lifter restored pleasure-seeking behavior independent of — and ahead of — its other antidepressant effects, in a National Institutes of Health trial. Within 40 minutes after a single infusion of ketamine, treatment-resistant depressed bipolar disorder patients experienced a reversal of a key symptom — loss of interest in pleasurable activities — which lasted up to 14 days. Brain scans traced the agent’s action to boosted activity in areas at the front and deep in the right hemisphere of the brain.
The research is in Translational Psychiatry. (full open access)
Research: “Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression” by N Lally, A C Nugent, D A Luckenbaugh, R Ameli, J P Roiser and C A Zarate in Translational Psychiatry. doi:10.1038/tp.2014.105
Image: PET scans revealed that ketamine rapidly restored bipolar depressed patients’ ability to anticipate pleasurable experiences by boosting activity in the dorsal anterior cingulate cortex (yellow) and related circuitry. Picture shows PET scan data superimposed on anatomical MRI image. Credit NIH.
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